The use of psychoactive substances has remained a critical problem among adolescents not just in Kenya but globally. The strategies that have been put in place by the Kenya government and other stakeholders seem not to have been effective in empowering adolescents to say "no" to substance use. These strategies seem not to have been fully effective in empowering adolescents with intrinsic drug resistant skills to curb substance use. Life skills when enhanced among Kenyan youth were found to be effective in empowering them to develop safe and healthy behavior with regard to substance use prevention.