This book is designed to investigate the impact of Shrewdness, Self-Confidence, Depression and Neuroticism among College Students on Life Stress. An attempt is made to unravel the nature and extent of stressful life experiences among the college students. The objective of this work is to find out the relationship between Life Stress and these primary behavioral dimensions. The sample of the study consists of undergraduate students ranging between 16 to 25 years. The findings that Shrewdness, Self-confidence, Depression and Neuroticism had significant effect on life stress of the respondents and were explained in the light of previous findings and existing theories. Practical implications of the findings were made explicit and suggestions for future research work were made.