The first part reviews the history of Iran-United States relations, from the 1950s to the present day. Key events are placed in their historical and geopolitical context, in order to better understand the evolution of mistrust between the two countries. The second part examines more specifically the Iranian nuclear issue, from the 1979 Revolution to the denunciation of the 2015 agreement. Beyond the technical aspect, this section seeks to decipher the issues of sovereignty and national security under -jacent. The third part discusses the economic sanctions imposed by the United States and their impacts on Iran. It demonstrates how these punitive measures have gradually deteriorated bilateral relations while weakening the Iranian.